5. UK Effect of intensive blood glucose control with metformine on complications in overweight patients with type 2 diabetes (UKPDS 34). The Lancet 352: 351-365, 1998. (Nivel de evidencia tipo I. Recomendación Clase A).

6. UK ProspectiveDiabetes Study (UKDPS) Group. Intensive blood-glucose control with sulphonylureas or insulina compared with conventional treatment and risk of complications in patients with type2 diabetes (UKPDS 33). Lancet 352: 837-853, 1998. (Nivel de evidencia tipo I. Recomendación Clase A).

7. Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulina therapy preventsthe progression odf diabetic microvascular complicationsin Japanese patientrs with non-insulin-dependentdiabetes mellitus: a randomized prospective6 year study Diabetes Res Clin Pract 28: 103-111, 1995. (Nivel de evidencia tipo I. Recomendación Clase A).

8. Schwartz S, Raskin P, Fonseca V Graveline JF. Effect of troglitazone in insulin-treated patients with type II diabetes mellitus. New Engl J Med 338: 861-866, 1998. (Nivel de evidencia tipo I. Recomendación Clase A).

9. Maggs DG, Buchanan TA, Burant CF, et al. Metabolic effects of troglitazonemonotherapy in type 2 diabetes mellitus Ann Intern Med 128: 176-185, 1998. (Nivel de evidencia tipo I. Recomendación Clase A).

10. Inzuchi SE, Maggs DG, Spollett GR, et al. Efficacy and metabolic efects of metformin and troglitazone in type diabtes mellitus. New Engl J Med 338: 867-872, 1998. (Nivel de evidencia tipo I. Recomendación Clase A).
Autor: FUNDACION SANTAFE DE BOGOTA
 
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